Your appendix is attached to the beginning of your large intestine or colon. (Photo: Getty Images)

In the party that is your body, your appendix can seem like a wallflower. After all, you may not really notice your appendix until it gets inflamed. Then, it can get promptly removed. Otherwise what else does a dangling out-pouching from your large intestine really do?

Well, a study just published in Science Translational Medicine suggests the appendix may have more than meets the eye. Could microscopic findings in the appendix have something to do with the cause of Parkinson’s Disease?

As you may know, Parkinson’s Disease is a nervous system disorder that eventually affects the ability to move different parts of the body. Symptoms include shaking or tremors, muscle stiffness, slowing of movement, balance problems, and difficulty speaking and writing and can get progressively worse over time. These symptoms seem to result from the gradual loss of nerve cells in the brain that produce a neurotransmitter called dopamine. Neurotransmitters are chemicals that help pass electrical signals from nerve cell to nerve cell. Losing neurotransmitters disrupts these electrical signals and the movements that they govern. Actors Alan Alda and Michael J. Fox and singers Neil Diamond and Linda Ronstadt have raised needed awareness of Parkinson’s Disease by going public with their diagnoses.

Researchers are still trying to uncover the causes of Parkinson’s and this latest study offers some potential clues. Even though the damage in Parkinson’s Disease seems to be occurring in the brain, the research team led by Bryan Killinger and Viviane Labrie from the Van Andel Research Institute in Grand Rapids, Michigan, pursued a gut feeling. They wanted to further explore the theory that Parkinson’s Disease may start in the gut and then eventually climb into the brain.

How did this theory arise? Gastrointestinal symptoms like constipation can occur relatively early on in the course of Parkinson’s Disease. Also, cutting the vagus nerve used to be a treatment for stomach ulcers. The vagus connects the gut to the brain. There has been the observation that those who underwent such vagotomies seemed to have lower likelihood of eventually developing Parkinson’s. But again, the gut-brain connection for Parkinson’s Disease is still a theory without enough strong scientific evidence yet. 

This newest study actually consisted of 3 parts. The first part involved analyzing data from the Swedish National Patient Registry (SNPR) and Statistics Sweden on 1.698 million individuals who had been followed for up to 52-years. Of them, 551,647 had undergone an appendectomy at some point their lives. These people were 19.3% less likely to eventually develop Parkinson’s Disease than those who never had their appendixes removed and a 16.9% less likely than the general population. For those who ended up developing Parkinson’s Disease. Among those who had had an appendectomy, 1.17 out of every 1000 people ended up having a Parkinson’s Disease diagnosis compared to 1.4 out of every 1000 in the general population.

Part two of the study entailed analyzing data on 849 Parkinson’s Disease cases from the Parkinson’s Progression Markers Initiative (PPMI). Those who had had an appendectomy at least 30 years before the diagnosis tended to develop Parkinson’s Disease at a later age, on average 3.6 years years later, than those who had never had an appendectomy.

The third part of the study took samples of the appendixes of 48 people without Parkinson’s Disease and used immunohistochemistry to look for a protein called α-synuclein. Prior studies have found accumulations of this protein in the substantial nigra, a part of the brain that helps control body movement, of people with Parkinson’s Disease. Indeed, the research team for this study found collections of α-synuclein in the sample appendix tissues. Additionally, the team found that the amount of α-synuclein was increased in 6 samples of appendixes from patients with Parkinson’s. 

Here is a 3D illustration showing neurons containing Lewy bodies small red spheres which are deposits of proteins (alpha-synuclein) accumulated in the brain cells. (Photo: Getty Images)

Are these study findings strong enough for you to get an appendectomy just to prevent Parkinson’s Disease? Absolutely not. This study doesn’t even prove that the appendix has any relation to Parkinson’s Disease. The first 2 parts of the study merely showed correlations or associations. And as I have said time and time again, associations do not prove cause-and-effect. Remember, there is an “ass” in associations if you believe they do. People who are more likely to get appendectomies may have very different surrounding situations or life courses than those who don’t.

Regarding the third part of the study, the role of α-synuclein in Parkinson’s Disease is still unknown. Could it somehow cause the damage in Parkinson’s Disease or could it be a byproduct? There is always the chance that it could be just a bystander. More research is needed to know.

This study is a reminder that the connections between the gut and the rest of the body are probably more complex than we realize. Having your head up your “you know what” may not be just a saying. Your brain and your intestines are connected in many different ways. And your intestines are not just like a tube of toothpaste. They may be playing many complex roles, ranging from regulating your metabolism to helping your immune system. That makes what you are putting in your mouth, whether it’s food, beverages, medications, or smartphones, even more important. Stay tuned as this study only begins to get into the guts of Parkinson’s Disease research.

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Your appendix is connected to the start of your big intestinal tract or colon.( Picture: Getty Images)

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In the celebration that is your body, your appendix can appear like a wallflower. After all, you might not truly see your appendix up until it gets swollen. Then, it can get without delay gotten rid of. Otherwise what else does a dangling out-pouching from your big intestinal tract truly do?

Well, a research study simply released in Science Translational Medication recommends the appendix might have more than satisfies the eye. Could tiny findings in the appendix have something to do with the reason for Parkinson’s Illness?

As you might understand, Parkinson’s Illness is a nerve system condition that ultimately impacts the capability to move various parts of the body. Signs consist of shaking or tremblings, muscle tightness, slowing of motion, balance issues, and trouble speaking and composing and can get gradually even worse in time. These signs appear to arise from the progressive loss of afferent neuron in the brain that produce a neurotransmitter called dopamine. Neurotransmitters are chemicals that assist pass electrical signals from afferent neuron to afferent neuron. Losing neurotransmitters interrupts these electrical signals and the motions that they govern. Stars Alan Alda and Michael J. Fox and vocalists Neil Diamond and Linda Ronstadt have actually raised required awareness of Parkinson’s Illness by going public with their medical diagnoses.

Scientists are still attempting to reveal the reasons for Parkinson’s and this newest research study provides some possible ideas. Despite the fact that the damage in Parkinson’s Illness appears to be happening in the brain, the research study group led by Bryan Killinger and Viviane Labrie from the Van Andel Research Study Institute in Grand Rapids, Michigan, pursued a suspicion. They wished to even more check out the theory that Parkinson’s Illness might begin in the gut and after that ultimately climb up into the brain.

How did this theory emerge? Intestinal signs like irregularity can happen reasonably at an early stage in the course of Parkinson’s Illness. Likewise, cutting the vagus nerve utilized to be a treatment for stomach ulcers. The vagus links the gut to the brain. There has actually been the observation that those who went through such vagotomies appeared to have lower possibility of ultimately establishing Parkinson’s However once again, the gut-brain connection for Parkinson’s Illness is still a theory without enough strong clinical proof yet.

(************ )This most recent research study in fact included 3 parts. The very first part included examining information from the Swedish National Client Pc Registry (SNPR) and Stats Sweden on 1.698 million people who had actually been followed for approximately 52- years. Of them, 551,647 had actually gone through an appendectomy at some time their lives. These individuals were 193% less most likely to ultimately establish Parkinson’s Illness than those who never ever had their appendixes gotten rid of and a 16.9% less most likely than the basic population. For those who wound up establishing Parkinson’s Illness. Amongst those who had actually had an appendectomy, 1.17 out of every 1000 individuals wound up having a Parkinson’s Illness medical diagnosis compared to 1.4 out of every 1000 in the basic population.

Sequel of the research study involved examining information on 849 Parkinson’s Illness cases from the Parkinson’s Development Markers Effort (PPMI). Those who had actually had an appendectomy a minimum of 30 years prior to the medical diagnosis tended to establish Parkinson’s Illness at a later age, usually 3.6 years years later on, than those who had never ever had an appendectomy.

The 3rd part of the research study took samples of the appendixes of 48 individuals without Parkinson’s Illness and utilized immunohistochemistry to try to find a protein called α-synuclein. Previous research studies have actually discovered build-ups of this protein in the significant nigra, a part of the brain that assists control body language, of individuals with Parkinson’s Illness. Undoubtedly, the research study group for this research study discovered collections of α-synuclein in the sample appendix tissues. In addition, the group discovered that the quantity of α-synuclein was increased in 6 samples of appendixes from clients with Parkinson’s.

Here is a 3D illustration revealing nerve cells consisting of Lewy bodies little red spheres which are deposits of proteins (alpha-synuclein) collected in the brain cells. (Picture: Getty Images)

Are these research study findings strong enough for you to get an appendectomy simply to avoid Parkinson’s Illness? Never. This research study does not even show that the appendix has any relation to Parkinson’s Illness. The very first 2 parts of the research study simply revealed connections or associations. And as I have actually stated time and time once again, associations do not show cause-and-effect. Keep in mind, there is an “ass” in associations if you think they do. Individuals who are most likely to get appendectomies might have really various surrounding scenarios or life courses than those who do not.

Concerning the 3rd part of the research study, the function of α-synuclein in Parkinson’s Illness is still unidentified. Could it in some way trigger the damage in Parkinson’s Illness or could it be a by-product? There is constantly the possibility that it might be simply a spectator. More research study is required to understand.

This research study is a tip that the connections in between the gut and the rest of the body are most likely more complicated than we understand. Having your direct your “you understand what” might not be simply a stating. Your brain and your intestinal tracts are linked in various methods. And your intestinal tracts are not much like a tube of tooth paste. They might be playing lots of complicated functions, varying from managing your metabolic process to assisting your body immune system. That makes what you are putting in your mouth, whether it’s food, drinks, medications, or mobile phones, much more crucial. Stay tuned as this research study just starts to enter the guts of Parkinson’s Illness research study.

” readability =”88
1375670531″ >

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Your appendix is connected to the start of your big intestinal tract or colon. (Picture: Getty Images)

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In the celebration that is your body, your appendix can appear like a wallflower. After all, you might not truly see your appendix up until it gets swollen. Then, it can get without delay gotten rid of. Otherwise what else does a dangling out-pouching from your big intestinal tract truly do?

Well, a research study simply released in Science Translational Medication recommends the appendix might have more than satisfies the eye. Could tiny findings in the appendix have something to do with the reason for Parkinson’s Illness?

As you might understand, Parkinson’s Illness is a nerve system condition that ultimately impacts the capability to move various parts of the body. Signs consist of shaking or tremblings, muscle tightness, slowing of motion, balance issues, and trouble speaking and composing and can get gradually even worse in time. These signs appear to arise from the progressive loss of afferent neuron in the brain that produce a neurotransmitter called dopamine. Neurotransmitters are chemicals that assist pass electrical signals from afferent neuron to afferent neuron. Losing neurotransmitters interrupts these electrical signals and the motions that they govern. Stars Alan Alda and Michael J. Fox and vocalists Neil Diamond and Linda Ronstadt have actually raised required awareness of Parkinson’s Illness by going public with their medical diagnoses.

Scientists are still attempting to reveal the reasons for Parkinson’s and this newest research study provides some possible ideas. Despite the fact that the damage in Parkinson’s Illness appears to be happening in the brain, the research study group led by Bryan Killinger and Viviane Labrie from the Van Andel Research Study Institute in Grand Rapids, Michigan, pursued a suspicion. They wished to even more check out the theory that Parkinson’s Illness might begin in the gut and after that ultimately climb up into the brain.

How did this theory emerge? Intestinal signs like irregularity can happen reasonably at an early stage in the course of Parkinson’s Illness. Likewise, cutting the vagus nerve utilized to be a treatment for stomach ulcers. The vagus links the gut to the brain. There has actually been the observation that those who went through such vagotomies appeared to have lower possibility of ultimately establishing Parkinson’s However once again, the gut-brain connection for Parkinson’s Illness is still a theory without enough strong clinical proof yet.

This most recent research study in fact included 3 parts. The very first part included examining information from the Swedish National Client Pc Registry (SNPR) and Stats Sweden on 1. 698 million people who had actually been followed for approximately 52 – years. Of them, 551, 647 had actually gone through an appendectomy at some time their lives. These individuals were 19.3 % less most likely to ultimately establish Parkinson’s Illness than those who never ever had their appendixes gotten rid of and a 16.9 % less most likely than the basic population. For those who wound up establishing Parkinson’s Illness. Amongst those who had actually had an appendectomy, 1. 17 out of every 1000 individuals wound up having a Parkinson’s Illness medical diagnosis compared to 1.4 out of every 1000 in the basic population.

Sequel of the research study involved examining information on 849 Parkinson’s Illness cases from the Parkinson’s Development Markers Effort (PPMI). Those who had actually had an appendectomy a minimum of 30 years prior to the medical diagnosis tended to establish Parkinson’s Illness at a later age, usually 3.6 years years later on, than those who had never ever had an appendectomy.

The 3rd part of the research study took samples of the appendixes of 48 individuals without Parkinson’s Illness and utilized immunohistochemistry to try to find a protein called α-synuclein. Previous research studies have actually discovered build-ups of this protein in the significant nigra, a part of the brain that assists control body language, of individuals with Parkinson’s Illness. Undoubtedly, the research study group for this research study discovered collections of α-synuclein in the sample appendix tissues. In addition, the group discovered that the quantity of α-synuclein was increased in 6 samples of appendixes from clients with Parkinson’s.

.

.

Here is a 3D illustration revealing nerve cells consisting of Lewy bodies little red spheres which are deposits of proteins (alpha-synuclein) collected in the brain cells. (Picture: Getty Images)

.

.

Are these research study findings strong enough for you to get an appendectomy simply to avoid Parkinson’s Illness? Never. This research study does not even show that the appendix has any relation to Parkinson’s Illness. The very first 2 parts of the research study simply revealed connections or associations. And as I have actually stated time and time once again, associations do not show cause-and-effect. Keep in mind, there is an “ass” in associations if you think they do. Individuals who are most likely to get appendectomies might have really various surrounding scenarios or life courses than those who do not.

Concerning the 3rd part of the research study, the function of α-synuclein in Parkinson’s Illness is still unidentified. Could it in some way trigger the damage in Parkinson’s Illness or could it be a by-product? There is constantly the possibility that it might be simply a spectator. More research study is required to understand.

This research study is a tip that the connections in between the gut and the rest of the body are most likely more complicated than we understand. Having your direct your “you understand what” might not be simply a stating. Your brain and your intestinal tracts are linked in various methods. And your intestinal tracts are not much like a tube of tooth paste. They might be playing lots of complicated functions, varying from managing your metabolic process to assisting your body immune system. That makes what you are putting in your mouth, whether it’s food, drinks, medications, or mobile phones, much more crucial. Stay tuned as this research study just starts to enter the guts of Parkinson’s Illness research study.

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