A new study suggests that certain gut bacteria may be involved in depression, but more work is needed to confirm this. Photo credit: Getty Royalty Free

A new study looking at the gut bacteria of over 1,000 people in Belgium has found a possible link between certain types of bacteria and depression.

The study published today in Nature Microbiology combined data from the microbiomes of 1,054 people enrolled in the Flemish Gut Flora project with self-reported and physician-diagnosed depression data. Using bioinformatics analyses, the researchers were able to identify certain groups of bacteria, which were either positively or negatively correlated with mental health.

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Two groups of bacteria in particular, Coprococcus and Dialister, were consistently found to be at low numbers in people with depression. The scientists then checked their findings on another cohort of 1,063 people involved in a similar study in The Netherlands and found the same result.

“This is the first time this kind of work has been done in such a large scale in humans. Most previous work has been done in animal models,” said Jeroen Raes, Professor at the Catholic University of Leuven in Belgium and Flemish Institute of Biotechnology and lead author of the study.

The research also suggests that some bacterial species in the microbiome may be able to produce or breakdown molecules that interact with the human nervous system. They looked at bacterial DNA from fecal samples in a subset of the study group, finding that the gut microbiome may be able to synthesize molecules such as seratonin and dopamine, which are found in abnormal levels in people with depression. People with treatment-resistant depression had microbiomes that were less-likely to be able to synthesize these molecules than healthy people.

“We don’t yet know whether these neuroactive compounds produced in the gut can reach the brain. Can they traverse the blood-brain-barrier? Or perhaps they act directly on the vagus nerve in the intestines, which sends signals directly to the brain,” said Raes.

Raes is very keen to point out that all of this work still has to be done and there are many unknowns, but there are plans underway to figure some of them out.

“Our goal would be to isolate these specific bacteria and culture them in animal models to see if they elicit or change behavioral traits. If this is proven then they next step would be to set up human trials to see if procuring these bacteria can improve symptoms in people with depression,” said Raes.

There are also a few limitations to the current study. The researchers looked at thousands of microbiomes in Europe and the results are likely to be applicable throughout the Western world, but it is currently not known whether this extends to places such as Asia and Africa, due to different diets.

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Despite this, the sheer number of people involved in the study and the analysis methods used make it a formidable piece of work showing that the microbiome is likely to be related to mental health.

“This is a creative and wholistic approach to the complex human biology of depression. We need to follow every thread that relates to depression spanning genetics, imaging, psychotherapy and more novel angles such as this. I look forward to learning more about this work,” said Ken Duckworth M.D., medical director of the National Alliance on Mental Illness.

The microbiome is undoubtedly one of the hottest topics in medical research at the moment, having been linked to numerous diseases such as multiple sclerosis and even childhood leukemia. The world’s largest cancer charity, Cancer Research UK also recently staked $25 million on an ambitous research project led by scientists at Harvard Medical School and the Dana Faber Cancer Institute to uncover links between the microbiome and colorectal cancer. And the research papers delving more in to the microbiome are coming thick and fast.

“I’m amazed by the breadth of diseases that the microbiome has been associated with. Although I’m a believer that the microbiome is likely to be involved in many diseases, I don’t necessarily think all of the early studies will be replicated,” said Raes.

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Another study also published today in Nature Biotechnology by a different group of scientists has discovered over 100 brand new bacterial species in the human gut. The reseachers sequenced bacteria from samples of feces given by 20 people from the UK and Canada and found 273 seperate bacterial species. The work has contributed to a considerable and growing database of the composition of the human microbiome.

“At this moment there is not enough evidence to say that modulating the microbiome is a treatment for depression. However, general healthy advice never hurts. The gut microbiome is always helped by a good diet full of fibre and lots of varied fruits and vegetables,” said Raes.

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(******** )A brand-new research study recommends that particular gut germs might be associated with anxiety, however more work is required to verify this. Image credit: Getty Royalty Free

A brand-new research study taking a look at the gut germs of over 1,000 individuals in Belgium has actually discovered a possible link in between particular kinds of germs and anxiety.

The research study released today in Nature Microbiology integrated information from the microbiomes of 1,054 individuals registered in the Flemish Gut Plants job with self-reported and physician-diagnosed anxiety information. Utilizing bioinformatics analyses, the scientists had the ability to recognize particular groups of germs, which were either favorably or adversely associated with psychological health.

(**************** )SHORT ARTICLE CONTINUES AFTER AD

2 groups of germs in specific, Coprococcus and Dialister, were regularly discovered to be at low numbers in individuals with anxiety. The researchers then inspected their findings on another associate of 1,063 individuals associated with a comparable research study in The Netherlands and discovered the very same outcome.

” This is the very first time this sort of work has actually been carried out in such a big scale in people. A lot of previous work has actually been carried out in animal designs,” stated Jeroen Raes, Teacher at the Catholic University of Leuven in Belgium and Flemish Institute of Biotechnology and lead author of the research study.

The research study likewise recommends that some bacterial types in the microbiome might have the ability to produce or breakdown particles that engage with the human nerve system. They took a look at bacterial DNA from fecal samples in a subset of the study hall, discovering that the gut microbiome might have the ability to manufacture particles such as seratonin and dopamine, which are discovered in irregular levels in individuals with anxiety. Individuals with treatment-resistant anxiety had microbiomes that were less-likely to be able to manufacture these particles than healthy individuals.

” We do not yet understand whether these neuroactive substances produced in the gut can reach the brain. Can they pass through the blood-brain-barrier? Or maybe they act straight on the vagus nerve in the intestinal tracts, which sends out signals straight to the brain,” stated Raes.

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Raes is extremely eager to mention that all of this work still needs to be done and there are lots of unknowns, however there are strategies underway to figure a few of them out.

” Our objective would be to separate these particular germs and culture them in animal designs to see if they generate or alter behavioral characteristics. If this is shown then they next action would be to establish human trials to see if obtaining these germs can enhance signs in individuals with anxiety,” stated Raes.

There are likewise a couple of constraints to the existing research study. The scientists took a look at countless microbiomes in Europe and the outcomes are most likely to be appropriate throughout the Western world, however it is presently not understood whether this reaches locations such as Asia and Africa, due to various diet plans.

(**************** )SHORT ARTICLE CONTINUES AFTER AD

In Spite Of this, the large variety of individuals associated with the research study and the analysis techniques utilized make it a powerful piece of work revealing that the microbiome is most likely to be associated with psychological health.

” This is an innovative and wholistic method to the complicated human biology of anxiety. We require to follow every thread that associates with anxiety covering genes, imaging, psychiatric therapy and more unique angles such as this. I eagerly anticipate finding out more about this work,” stated Ken Duckworth M.D., medical director of the National Alliance on Mental Disorder.

The microbiome is unquestionably among the most popular subjects in medical research study at the minute, having actually been connected to many illness such as numerous sclerosis and even youth leukemia The world’s biggest cancer charity, Cancer Research study UK likewise just recently staked $25 million on an ambitous research study job led by researchers at Harvard Medical School and the Dana Faber Cancer Institute to reveal links in between the microbiome and colorectal cancer. And the research study documents diving more in to the microbiome are coming thick and quick.

” I’m surprised by the breadth of illness that the microbiome has actually been connected with. Although I’m a follower that the microbiome is most likely to be associated with lots of illness, I do not always believe all of the early research studies will be reproduced,” stated Raes.

(**************** )SHORT ARTICLE CONTINUES AFTER AD

Another research study likewise released today in Nature Biotechnology by a various group of researchers has actually found over 100 brand name brand-new bacterial types in the human gut. The reseachers sequenced germs from samples of feces provided by 20 individuals from the UK and Canada and discovered 273 seperate bacterial types. The work has actually added to a substantial and growing database of the structure of the human microbiome.

” At this minute there is inadequate proof to state that regulating the microbiome is a treatment for anxiety. Nevertheless, basic healthy guidance never ever injures. The gut microbiome is constantly assisted by an excellent diet plan loaded with fiber and great deals of different vegetables and fruits,” stated Raes.

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866022933011″ >

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A brand-new research study recommends that particular gut germs might be associated with anxiety, however more work is required to verify this. Image credit: Getty Royalty Free

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A brand-new research study taking a look at the gut germs of over 1, 000 individuals in Belgium has actually discovered a possible link in between particular kinds of germs and anxiety.

The research study released today in Nature Microbiology integrated information from the microbiomes of 1, 054 individuals registered in the Flemish Gut Plants job with self-reported and physician-diagnosed anxiety information. Utilizing bioinformatics analyses, the scientists had the ability to recognize particular groups of germs, which were either favorably or adversely associated with psychological health.

. SHORT ARTICLE CONTINUES AFTER AD

.

2 groups of germs in specific, Coprococcus and Dialister , were regularly discovered to be at low numbers in individuals with anxiety. The researchers then inspected their findings on another associate of 1, 063 individuals associated with a comparable research study in The Netherlands and discovered the very same outcome.

“This is the very first time this sort of work has actually been carried out in such a big scale in people. A lot of previous work has actually been carried out in animal designs,” stated Jeroen Raes, Teacher at the Catholic University of Leuven in Belgium and Flemish Institute of Biotechnology and lead author of the research study.

The research study likewise recommends that some bacterial types in the microbiome might have the ability to produce or breakdown particles that engage with the human nerve system. They took a look at bacterial DNA from fecal samples in a subset of the study hall, discovering that the gut microbiome might have the ability to manufacture particles such as seratonin and dopamine, which are discovered in irregular levels in individuals with anxiety. Individuals with treatment-resistant anxiety had microbiomes that were less-likely to be able to manufacture these particles than healthy individuals.

“We do not yet understand whether these neuroactive substances produced in the gut can reach the brain. Can they pass through the blood-brain-barrier? Or maybe they act straight on the vagus nerve in the intestinal tracts, which sends out signals straight to the brain,” stated Raes.

Raes is extremely eager to mention that all of this work still needs to be done and there are lots of unknowns, however there are strategies underway to figure a few of them out.

“Our objective would be to separate these particular germs and culture them in animal designs to see if they generate or alter behavioral characteristics. If this is shown then they next action would be to establish human trials to see if obtaining these germs can enhance signs in individuals with anxiety,” stated Raes.

There are likewise a couple of constraints to the existing research study. The scientists took a look at countless microbiomes in Europe and the outcomes are most likely to be appropriate throughout the Western world, however it is presently not understood whether this reaches locations such as Asia and Africa, due to various diet plans.

. SHORT ARTICLE CONTINUES AFTER AD

.

In Spite Of this, the large variety of individuals associated with the research study and the analysis techniques utilized make it a powerful piece of work revealing that the microbiome is most likely to be associated with psychological health.

“This is an innovative and wholistic method to the complicated human biology of anxiety. We require to follow every thread that associates with anxiety covering genes, imaging, psychiatric therapy and more unique angles such as this. I eagerly anticipate finding out more about this work,” stated Ken Duckworth M.D., medical director of the National Alliance on Mental Disorder.

The microbiome is unquestionably among the most popular subjects in medical research study at the minute, having actually been connected to many illness such as numerous sclerosis and even youth leukemia The world’s biggest cancer charity, Cancer Research study UK likewise just recently staked $ 25 million on an ambitous research study job led by researchers at Harvard Medical School and the Dana Faber Cancer Institute to reveal links in between the microbiome and colorectal cancer. And the research study documents diving more in to the microbiome are coming thick and quick.

“I’m surprised by the breadth of illness that the microbiome has actually been connected with. Although I’m a follower that the microbiome is most likely to be associated with lots of illness, I do not always believe all of the early research studies will be reproduced,” stated Raes.

. SHORT ARTICLE CONTINUES AFTER AD

.

Another research study likewise released today in Nature Biotechnology by a various group of researchers has actually found over 100 brand name brand-new bacterial types in the human gut. The reseachers sequenced germs from samples of feces provided by 20 individuals from the UK and Canada and discovered 273 seperate bacterial types. The work has actually added to a substantial and growing database of the structure of the human microbiome.

“At this minute there is inadequate proof to state that regulating the microbiome is a treatment for anxiety. Nevertheless, basic healthy guidance never ever injures. The gut microbiome is constantly assisted by an excellent diet plan loaded with fiber and great deals of different vegetables and fruits,” stated Raes.