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Results of a randomized clinical trial conducted at 102 sites in the United States and Puerto Rico among 9,361 adults aged 50 years or older were published in January in the Journal of the American Medical Association (JAMA).

“This is a landmark study in that it is the first trial of its size and scope to look at a modifiable risk factor for dementia and MCI,” said Lenore J. Launer, Ph.D., a senior investigator in the NIA Laboratory of Epidemiology and Population Sciences and co-author of the paper. “The study had a carefully designed hypothesis, used approved appropriate tools to assess dementia and MCI, was blinded for diagnosis, and got a good sample of older people.”

According to study authors, it’s the first randomized clinical trial demonstrating that an intervention significantly reduces the occurrence of MCI, “which is an established risk factor and often a precursor for dementia.” They also noted that intensive lowering of systolic blood pressure to less than 120 mmHg—which does reduce the risk of cardiovascular events and mortality—is safe for the brain. (The American Heart Association (AHA) considers blood pressure numbers of less than 120/80 mm Hg to be within the normal range.)

Secondary results of the Systolic Blood Pressure Intervention Trial (SPRINT) Memory and Cognition in Decreased Hypertension (SPRINT MIND) study are “the first to show an intervention that significantly reduces the occurrence of MCI, which is a well-established precursor of dementia,” reports the National Institutes of Health (NIH). “SPRINT MIND was an integral aspect of the initial design for SPRINT, a large, randomized clinical trial of intensive blood pressure lowering on cardiovascular and renal disease; both were funded by the National Institutes of Health.”

Richard J. Hodes, M.D., director of the National Institute on Aging (NIA), part of NIH and the lead institute on Alzheimer’s research, said results of the trial are good news as they provide researchers another piece of the puzzle in studying, and hopefully preventing, dementia. “Dementia continues to be a large public health challenge, and based on the primary results of this study, we still have yet to find an intervention strategy proven to reduce the risk of dementia,” Hodes said. “Nevertheless, the secondary results showing that intensive lowering of blood pressure may reduce risk for MCI, a known risk factor for dementia, gives us additional avenues to explore on the path to prevention.”

According to the NIH, people with MCI have more difficulty with cognition, thinking, remembering and reasoning, than normal for people their age. “Dementia is a more severe form of loss in cognitive functions that interferes with daily life. Alzheimer’s disease is the most common type of dementia. High blood pressure, or hypertension, is very common in persons over the age of 50 and a leading risk factor for heart disease, stroke, kidney failure, and a growing body of research suggests that it may increase risk for dementia later in life.”

The participants in SPRINT were adults 50 years and older who were at high risk for cardiovascular disease. “Results of the SPRINT trial, which ended early, showed that intensive blood pressure control, i.e., a systolic blood pressure target of less than 120 mmHg, compared to a standard target of less than 140 mmHg, reduced cardiovascular events and overall mortality,” the NIH reported. “Between November 2010 and March 2013 more than 9,300 participants were randomized to the two target groups with nearly 4,700 in each group.”

The SPRINT trial was stopped in August 2015, after 3.3 years of treatment “when the major beneficial effects of intensive blood pressure management on mortality and cardiovascular disease were discovered.” However, assessment for development of dementia and MCI continued for the full planned five years.

The NIH reported, “SPRINT MIND aimed to address whether intensive blood pressure control would also reduce the risk of developing dementia and cognitive impairment over the ensuing five years. Cognitive assessments were given to participants who had high blood pressure but no history of stroke or diabetes at the start of the trial, and over 91 percent had at least one follow up. Participants were classified into one of three categories: no cognitive impairment, MCI, or probable dementia.”

The primary results of the trial showed no real difference between standard and intensive treatment in participants who were diagnosed with dementia, according to the SPRINT MIND Research Group, including corresponding author Jeff D. Williamson, M.D., M.H.S., from Wake Forest School of Medicine, Winston-Salem, North Carolina. But the study did have fewer cases of dementia than expected, and the secondary results suggested that the intensive treatment reduced the risk of MCI and the combined risk of MCI and dementia. “Due to the success of the SPRINT trial on the cardiovascular outcomes, the study intervention was stopped early; as a result, participants were treated for a shorter period than originally planned,” NIH reported. “The authors concluded that the shorter time and the unexpected fewer cases of dementia may have made it difficult to determine the role of intensive blood pressure control on dementia.”

“The fact that there was still an MCI result when the study was cut short makes these results encouraging,” explained Laurie Ryan, Ph.D., chief of the Dementias of Aging Branch in the NIA Division of Neuroscience and program lead for SPRINT MIND. “This study is in line with where the field of dementia research is going: preventing memory loss earlier. Much like we have research-based interventions for heart health and cancer prevention, we hope to have guidance based on this and subsequent studies that will more definitively show how to slow or even stop dementia well before symptoms appear.”

There are no proven interventions that prevent or delay the incidence of MCI or dementia, the authors noted. The NIH encouraged people to consult with their healthcare providers in deciding the best blood pressure goals and how to achieve them (for example, introducing lifestyle changes such as diet and exercise; or lifestyle changes with addition of blood pressure medications).

Results of the trial also emphasize the link between vascular health and the brain. The NIH, in 2016, launched the Mind Your Risks®—a public health campaign designed to educate people about the importance of controlling blood pressure in midlife (from the ages of 45 to 65) to help reduce the risk of having a stroke and possibly developing dementia later in life.

The Mind Your Risks® campaign comes out of the National Institute of Neurological Disorders and Stroke (NINDS), one of the institutes at the NIH. With it, the NIH emphasizes the work of scientists all over the world who are learning more about cellular changes in the brain that can lead to dementia, including Alzheimer’s disease. They hope this research will lead to new treatments that will prevent or slow the most serious forms of dementia.

In an attempt to educate people that the risks of high blood pressure go beyond heart attack and stroke, the NINDS holds that “Many people with high blood pressure know that they could be at risk for stroke and heart attack. However, too many people, despite what they may know, still are not motivated by these facts to get their high blood pressure under control. Now a new risk of high blood pressure is emerging: the possible connection between uncontrolled blood pressure and dementia. Important new studies link high blood pressure, especially in midlife, to an increased risk for dementia later in life.”

“People need to think about how they can decrease their chances of developing dementia in later life,” said NINDS director, Walter Koroshetz, M.D. “With what we now know, controlling hypertension is at the top of the list.”

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Reducing high blood pressure does not lower the threat for dementia, however it does lower the effect of moderate cognitive problems (MCI), which might be the next finest thing in the research study of dementia avoidance.(** )(*** )(**** )

Health Care Stethoscope Blue Background Medical(*********** )Getty

Outcomes of a randomized medical trial performed at 102 websites in the United States and Puerto Rico amongst 9,361 grownups aged 50 years or older were released in January in the Journal of the American Medical Association(JAMA).

” This is a landmark research study because it is the very first trial of its size and scope to take a look at a flexible threat aspect for dementia and MCI,” stated Lenore J. Launer, Ph.D., a senior detective in the NIA Lab of Public Health and Population Sciences and co-author of the paper. “The research study had actually a thoroughly created hypothesis, utilized authorized suitable tools to examine dementia and MCI, was blinded for medical diagnosis, and got a great sample of older individuals.”

According to study authors, it’s the very first randomized medical trial showing that an intervention considerably minimizes the event of MCI, “which is a recognized threat aspect and typically a precursor for dementia.” They likewise kept in mind that extensive lowering of systolic high blood pressure to less than 120 mmHg– which does lower the threat of cardiovascular occasions and death– is safe for the brain. (The American Heart Association (AHA) thinks about high blood pressure varieties of less than 120/80 mm Hg to be within the typical variety)

Secondary outcomes of the Systolic High Blood Pressure Intervention Trial (SPRINT) Memory and Cognition in Reduced High Blood Pressure (SPRINT MIND) research study are “the very first to reveal an intervention that considerably minimizes the event of MCI, which is a reputable precursor of dementia,” reports the National Institutes of Health (NIH). “SPRINT MIND was an essential element of the preliminary style for SPRINT, a big, randomized medical trial of extensive high blood pressure reducing on cardiovascular and kidney illness; both were moneyed by the National Institutes of Health.”

Richard J. Hodes, M.D., director of the National Institute on Aging (NIA), part of NIH and the lead institute on Alzheimer’s research study, stated outcomes of the trial are great news as they supply scientists another piece of the puzzle in studying, and ideally avoiding, dementia. “Dementia continues to be a big public health obstacle, and based upon the main outcomes of this research study, we still have yet to discover an intervention technique shown to lower the threat of dementia,” Hodes stated. “Nonetheless, the secondary outcomes revealing that extensive lowering of high blood pressure might lower threat for MCI, a recognized threat aspect for dementia, provides us extra opportunities to check out on the course to avoidance.”

According to the NIH, individuals with MCI have more problem with cognition, believing, keeping in mind and thinking, than typical for individuals their age. “ Dementia is a more serious type of loss in cognitive functions that disrupts life. Alzheimer’s illness is the most typical kind of dementia. Hypertension, or high blood pressure, is really typical personallies over the age of 50 and a leading threat aspect for heart problem, stroke, kidney failure, and a growing body of research study recommends that it might increase threat for dementia later on in life.”

The individuals in SPRINT were grownups 50 years and older who were at high threat for heart disease. “ Outcomes of the SPRINT trial, which ended early, revealed that extensive high blood pressure control, i.e., a systolic high blood pressure target of less than 120 mmHg, compared to a basic target of less than 140 mmHg, minimized cardiovascular occasions and total death,” the NIH reported. “In Between November 2010 and March 2013 more than 9,300 individuals were randomized to the 2 target groups with almost 4,700 in each group.”

The SPRINT trial was dropped in August 2015, after 3.3 years of treatment “when the significant helpful results of extensive high blood pressure management on death and heart disease were found.” Nevertheless, evaluation for advancement of dementia and MCI continued for the complete scheduled 5 years.

The NIH reported, “SPRINT MIND intended to resolve whether extensive high blood pressure control would likewise lower the threat of establishing dementia and cognitive problems over the occurring 5 years. Cognitive evaluations were provided to individuals who had hypertension however no history of stroke or diabetes at the start of the trial, and over 91 percent had at least one follow up. Individuals were categorized into among 3 classifications: no cognitive problems, MCI, or likely dementia.”

The main outcomes of the trial revealed no genuine distinction in between basic and extensive treatment in individuals who were identified with dementia, according to the SPRINT MIND Research study Group, consisting of matching author Jeff D. Williamson, M.D., M.H.S., from Wake Forest School of Medication, Winston-Salem, North Carolina. However the research study did have less cases of dementia than anticipated, and the secondary outcomes recommended that the extensive treatment minimized the threat of MCI and the combined threat of MCI and dementia. “Due to the success of the SPRINT trial on the cardiovascular results, the research study intervention was stopped early; as an outcome, individuals were dealt with for a much shorter duration than initially prepared,” NIH reported. “The authors concluded that the much shorter time and the unanticipated less cases of dementia might have made it hard to figure out the function of extensive high blood pressure control on dementia.”

” The reality that there was still an MCI result when the research study was interrupted makes these outcomes motivating,” discussed Laurie Ryan, Ph.D., chief of the Dementias of Aging Branch in the NIA Department of Neuroscience and program lead for SPRINT MIND. “This research study remains in line with where the field of dementia research study is going: avoiding amnesia previously. Similar to we have research-based interventions for heart health and cancer avoidance, we wish to have actually assistance based upon this and subsequent research studies that will more definitively demonstrate how to slow or perhaps stop dementia well prior to signs appear.”

There are no tested interventions that avoid or postpone the occurrence of MCI or dementia, the authors kept in mind. The NIH motivated individuals to seek advice from their doctor in choosing the very best high blood pressure objectives and how to attain them (for instance, presenting way of life modifications such as diet plan and workout; or way of life modifications with addition of high blood pressure medications).

Outcomes of the trial likewise highlight the link in between vascular health and the brain. The NIH, in 2016, introduced the Mind Your Dangers ®— a public health project created to inform individuals about the significance of managing high blood pressure in midlife (from the ages of 45 to 65) to help in reducing the threat of having a stroke and perhaps establishing dementia later on in life.

The Mind Your Dangers ® project comes out of the National Institute of Neurological Conditions and Stroke (NINDS), among the institutes at the NIH. With it, the NIH stresses the work of researchers all over the world who are discovering more about cellular modifications in the brain that can cause dementia, consisting of Alzheimer’s illness. They hope this research study will cause brand-new treatments that will avoid or slow the most severe types of dementia.

In an effort to inform individuals that the dangers of hypertension exceed cardiovascular disease and stroke, the NINDS holds that “Lots of people with hypertension understand that they might be at threat for stroke and cardiovascular disease. Nevertheless, a lot of individuals, in spite of what they might understand, still are not inspired by these realities to get their hypertension under control. Now a brand-new threat of hypertension is emerging: the possible connection in between unrestrained high blood pressure and dementia. Essential brand-new research studies connect hypertension, particularly in midlife, to an increased threat for dementia later on in life.”

” Individuals require to think of how they can reduce their opportunities of establishing dementia in later life,” stated NINDS director, Walter Koroshetz, M.D. “With what we now understand, managing high blood pressure is at the top of the list.”

” readability =”159
49951585573″ >

Reducing high blood pressure does not lower the threat for dementia, however it does lower the effect of moderate cognitive problems (MCI), which might be the next finest thing in the research study of dementia avoidance.

.

.

Health Care Stethoscope Blue Background Medical Getty

.

.

Outcomes of a randomized medical trial performed at 102 websites in the United States and Puerto Rico amongst 9, 361 grownups aged 50 years or older were released in January in the Journal of the American Medical Association (JAMA).

“This is a landmark research study because it is the very first trial of its size and scope to take a look at a flexible threat aspect for dementia and MCI,” stated Lenore J. Launer, Ph.D., a senior detective in the NIA Lab of Public Health and Population Sciences and co-author of the paper. “The research study had actually a thoroughly created hypothesis, utilized authorized suitable tools to examine dementia and MCI, was blinded for medical diagnosis, and got a great sample of older individuals.”

According to study authors, it’s the very first randomized medical trial showing that an intervention considerably minimizes the event of MCI, “which is a recognized threat aspect and typically a precursor for dementia.” They likewise kept in mind that extensive lowering of systolic high blood pressure to less than 120 mmHg– which does lower the threat of cardiovascular occasions and death– is safe for the brain. (The American Heart Association (AHA) thinks about high blood pressure varieties of less than 120/ 80 mm Hg to be within the typical variety .)

Secondary outcomes of the Systolic High Blood Pressure Intervention Trial (SPRINT) Memory and Cognition in Reduced High Blood Pressure (SPRINT MIND) research study are “the very first to reveal an intervention that considerably minimizes the event of MCI, which is a reputable precursor of dementia,” reports the National Institutes of Health (NIH). “SPRINT MIND was an essential element of the preliminary style for SPRINT, a big, randomized medical trial of extensive high blood pressure reducing on cardiovascular and kidney illness; both were moneyed by the National Institutes of Health.”

Richard J. Hodes, M.D., director of the National Institute on Aging (NIA), part of NIH and the lead institute on Alzheimer’s research study, stated outcomes of the trial are great news as they supply scientists another piece of the puzzle in studying, and ideally avoiding, dementia. “Dementia continues to be a big public health obstacle, and based upon the main outcomes of this research study, we still have yet to discover an intervention technique shown to lower the threat of dementia,” Hodes stated. “Nonetheless, the secondary outcomes revealing that extensive lowering of high blood pressure might lower threat for MCI, a recognized threat aspect for dementia, provides us extra opportunities to check out on the course to avoidance.”

According to the NIH, individuals with MCI have more problem with cognition, believing, keeping in mind and thinking, than typical for individuals their age.” Dementia is a more serious type of loss in cognitive functions that disrupts life. Alzheimer’s illness is the most typical kind of dementia. Hypertension, or high blood pressure, is really typical personallies over the age of 50 and a leading threat aspect for heart problem, stroke, kidney failure, and a growing body of research study recommends that it might increase threat for dementia later on in life.”

The individuals in SPRINT were grownups 50 years and older who were at high threat for heart disease.” Outcomes of the SPRINT trial , which ended early, revealed that extensive high blood pressure control, i.e., a systolic high blood pressure target of less than 120 mmHg, compared to a basic target of less than 140 mmHg, minimized cardiovascular occasions and total death,” the NIH reported. “In Between November 2010 and March 2013 more than 9, 300 individuals were randomized to the 2 target groups with almost 4, 700 in each group.”

The SPRINT trial was dropped in August 2015, after 3.3 years of treatment “when the significant helpful results of extensive high blood pressure management on death and heart disease were found.” Nevertheless, evaluation for advancement of dementia and MCI continued for the complete scheduled 5 years.

.

The NIH reported, “SPRINT MIND intended to resolve whether extensive high blood pressure control would likewise lower the threat of establishing dementia and cognitive problems over the occurring 5 years. Cognitive evaluations were provided to individuals who had hypertension however no history of stroke or diabetes at the start of the trial, and over 91 percent had at least one follow up. Individuals were categorized into among 3 classifications: no cognitive problems, MCI, or likely dementia.”

.

The main outcomes of the trial revealed no genuine distinction in between basic and extensive treatment in individuals who were identified with dementia, according to the SPRINT MIND Research study Group, consisting of matching author Jeff D. Williamson, M.D., M.H.S., from Wake Forest School of Medication, Winston-Salem, North Carolina. However the research study did have less cases of dementia than anticipated, and the secondary outcomes recommended that the extensive treatment minimized the threat of MCI and the combined threat of MCI and dementia. “Due to the success of the SPRINT trial on the cardiovascular results, the research study intervention was stopped early; as an outcome, individuals were dealt with for a much shorter duration than initially prepared,” NIH reported. “The authors concluded that the much shorter time and the unanticipated less cases of dementia might have made it hard to figure out the function of extensive high blood pressure control on dementia.”

.

“The reality that there was still an MCI result when the research study was interrupted makes these outcomes motivating,” discussed Laurie Ryan, Ph.D., chief of the Dementias of Aging Branch in the NIA Department of Neuroscience and program lead for SPRINT MIND. “This research study remains in line with where the field of dementia research study is going: avoiding amnesia previously. Similar to we have research-based interventions for heart health and cancer avoidance, we wish to have actually assistance based upon this and subsequent research studies that will more definitively demonstrate how to slow or perhaps stop dementia well prior to signs appear.”

.

There are no tested interventions that avoid or postpone the occurrence of MCI or dementia, the authors kept in mind. The NIH motivated individuals to seek advice from their doctor in choosing the very best high blood pressure objectives and how to attain them (for instance, presenting way of life modifications such as diet plan and workout; or way of life modifications with addition of high blood pressure medications).

Outcomes of the trial likewise highlight the link in between vascular health and the brain. The NIH, in 2016, introduced the Mind Your Dangers ® — a public health project created to inform individuals about the significance of managing high blood pressure in midlife (from the ages of 45 to 65) to help in reducing the threat of having a stroke and perhaps establishing dementia later on in life.

The Mind Your Dangers ® project comes out of the National Institute of Neurological Conditions and Stroke (NINDS), among the institutes at the NIH. With it, the NIH stresses the work of researchers all over the world who are discovering more about cellular modifications in the brain that can cause dementia, consisting of Alzheimer’s illness. They hope this research study will cause brand-new treatments that will avoid or slow the most severe types of dementia.

In an effort to inform individuals that the dangers of hypertension exceed cardiovascular disease and stroke, the NINDS holds that “Lots of people with hypertension understand that they might be at threat for stroke and cardiovascular disease. Nevertheless, a lot of individuals, in spite of what they might understand, still are not inspired by these realities to get their hypertension under control. Now a brand-new threat of hypertension is emerging: the possible connection in between unrestrained high blood pressure and dementia. Essential brand-new research studies connect hypertension, particularly in midlife, to an increased threat for dementia later on in life.”

“Individuals require to think of how they can reduce their opportunities of establishing dementia in later life,” stated NINDS director, Walter Koroshetz, M.D. “With what we now understand, managing high blood pressure is at the top of the list.”