When Theranos, the beleaguered blood-testing business that’s now the topic of a book, documentaries, and a podcast, closed its doors in 2018, it signed up with a crop of health care start-ups that eventually didn’t measure up to financiers’ lofty expectations.

While none had the magnificent fall from grace that Theranos had, health care start-ups that raised 10s of millions and even numerous millions from financiers in the previous 5 years have actually eventually chosen to close their doors for one factor or another.

Here are 10 of the most significant health care start-ups that have not worked out in the previous couple of years, as highlighted by CB Insights.